Negoescu breast cancers . Analysis of Bax and Bcl - 2 expression in p 53 - immunopositive

نویسنده

  • S. Krajewski
چکیده

Krajewski et al. (1 ) have recently analyzed the relationship between p53 immunoreactivity and the level of Bcl-2 and Bax in breast cancers using immunohistochemistry, because recent data indicate that wild-type p53 can transcriptionally repress Bcl-2 expression while inducing the expression of Bax. Absence of p53 in knockout mice was associated with increased Bcl-2 and decreased Bax in some tissues (2). When the percentage of p53-immunopositive tumor cells was compared with the percentage of Bcl-2and Bax-immunopositive cells (as a continuous variable) in breast adenocarcinoma, a significant inverse correlation between Bcl-2 and

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تاریخ انتشار 2005