Negoescu breast cancers . Analysis of Bax and Bcl - 2 expression in p 53 - immunopositive
نویسنده
چکیده
Krajewski et al. (1 ) have recently analyzed the relationship between p53 immunoreactivity and the level of Bcl-2 and Bax in breast cancers using immunohistochemistry, because recent data indicate that wild-type p53 can transcriptionally repress Bcl-2 expression while inducing the expression of Bax. Absence of p53 in knockout mice was associated with increased Bcl-2 and decreased Bax in some tissues (2). When the percentage of p53-immunopositive tumor cells was compared with the percentage of Bcl-2and Bax-immunopositive cells (as a continuous variable) in breast adenocarcinoma, a significant inverse correlation between Bcl-2 and
منابع مشابه
Analysis of Bax and Bcl-2 expression in p53-immunopositive breast cancers.
Bax and Bcl-2 are proteins that regulate programmed cell death and apoptosis. The expression of these proteins can be regulated, at least in part, by the tumor suppressor p53, but the effects of p53 are highly tissue specific. In an effort to better understand the relation between p53 and the in vivo control of the expression of Bax and Bcl-2 in adenocarcinomas of the breast, we evaluated by im...
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